Database

BC-TFdb Transcription factors drivers in Breast Cancer Database

id Target Name DRUGBANK ID DRUG NAME DRUG GROUP PHARMACOLOGICAL ACTION ACTIONS
1 TP53 DB05404 AZD 3355 investigational unknown
2 TP53 DB08363 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine experimental unknown
3 TP53 DB00945 Acetylsalicylic acid approved, vet_approved unknown induceracetylation
4 TP53 DB01593 Zinc approved, investigational unknown
5 TP53 DB03347 Triethyl phosphate experimental unknown
6 TP53 DB14487 Zinc acetate approved, investigational unknown
7 TP53 DB14533 Zinc chloride approved, investigational unknown chaperone
8 TP53 DB14548 Zinc sulfate, unspecified form approved, experimental unknown chaperone
9 PIK3CA DB11772 Pilaralisib investigational unknown
10 PIK3CA DB05241 XL765 investigational unknown
11 PIK3CA DB08059 Wortmannin experimental unknown
12 PIK3CA DB00201 Caffeine approved unknown inhibitor
13 PIK3CA DB00171 ATP investigational, nutraceutical unknown
14 PIK3CA DB12483 Copanlisib approved, investigational yes inhibitor
15 PIK3CA DB12015 Alpelisib approved, investigational yes inhibitor
16 MYC DB08813 Nadroparin approved, investigational unknown inhibitor
17 MYC DB00945 Acetylsalicylic acid approved, vet_approved unknown downregulator
18 CCND1 DB01169 Arsenic trioxide approved, investigational yes antagonist
19 CCND1 DB11718 Encorafenib approved, investigational yes inhibitor
20 CCND1 DB00945 Acetylsalicylic acid approved, vet_approved unknown downregulator
21 CCND1 DB11752 Bryostatin 1 investigational unknown inhibitor
22 PTEN DB04327 Phosphatidylethanolamine experimental unknown substrate
23 ERBB2/HER2 DB01259 Lapatinib approved, investigational yes antagonist
24 ERBB2/HER2 DB00072 Trastuzumab approved, investigational yes antibody
25 ERBB2/HER2 DB04988 IGN311 investigational unknown
26 ERBB2/HER2 DB11973 Tesevatinib investigational unknown
27 ERBB2/HER2 DB05773 Trastuzumab emtansine approved, investigational yes antibody
28 ERBB2/HER2 DB05944 Varlitinib investigational unknown
29 ERBB2/HER2 DB11652 Tucatinib approved, investigational yes inhibitor
30 ERBB2/HER2 DB06021 AV-412 investigational unknown
31 ERBB2/HER2 DB06366 Pertuzumab approved yes inhibitor
32 ERBB2/HER2 DB08916 Afatinib approved yes inhibitor
33 ZNF703/FGFR1 DB00039 Palifermin approved unknown agonist
34 ZNF703/FGFR1 DB05014 XL999 investigational unknown
35 ZNF703/FGFR1 DB07525 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine experimental unknown
36 ZNF703/FGFR1 DB07840 (E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol experimental unknown
37 ZNF703/FGFR1 DB08577 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE experimental unknown
38 ZNF703/FGFR1 DB02058 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone experimental unknown
39 ZNF703/FGFR1 DB08896 Regorafenib approved yes inhibitor
40 ZNF703/FGFR1 DB08901 Ponatinib approved, investigational unknown inhibitor
41 ZNF703/FGFR1 DB00398 Sorafenib approved, investigational yes inhibitor
42 ZNF703/FGFR1 DB09078 Lenvatinib approved, investigational yes inhibitor
43 GATA3 DB00349 Clobazam approved, illicit yes other
44 GATA3 DB08848 Guvacine experimental unknown inhibitor
45 RB1 DB00030 Insulin human approved, investigational unknown
46 RB1 DB00071 Insulin pork approved unknown
47 MAP3K1 DB06061 AZD-8330 investigational unknown
48 MAP3K1 DB12010 Fostamatinib approved, investigational unknown inhibitor
49 MAP3K1 DB11967 Binimetinib approved, investigational yes inhibitor
50 MLL3/KMT2C DB14581 CPI-1205 investigational yes inhibitor
51 MLL3/KMT2C DB12887 Tazemetostat approved, investigational yes inhibitor
52 CDKN2A DB08818 Hyaluronic acid approved, vet_approved unknown binder
53 CDKN2A DB09130 Copper approved, investigational unknown
54 AKT1/PKBa DB02709 Resveratrol investigational unknown inhibitor
55 AKT1/PKBa DB06641 Perifosine investigational unknown
56 AKT1/PKBa DB07584 N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine experimental unknown
57 AKT1/PKBa DB01863 Inositol 1,3,4,5-Tetrakisphosphate experimental unknown
58 AKT1/PKBa DB01645 Genistein investigational unknown
59 AKT1/PKBa DB06486 Enzastaurin investigational unknown
60 AKT1/PKBa DB00171 ATP investigational, nutraceutical unknown
61 AKT1/PKBa DB01169 Arsenic trioxide approved, investigational unknown inducer
62 AKT1/PKBa DB05971 Archexin investigational unknown
63 AKT1/PKBa DB07585 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine experimental unknown
64 MDM2 DB02872 Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone experimental unknown
65 MDM2 DB04144 Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone experimental unknown
66 MDM2 DB01593 Zinc approved, investigational unknown
67 MDM2 DB14487 Zinc acetate approved, investigational unknown
68 MDM2 DB14533 Zinc chloride approved, investigational unknown binder
69 MDM2 DB14548 Zinc sulfate, unspecified form approved, experimental unknown binder
70 SF3B1 DB14017 H3B-8800 investigational yes inhibitor
71 IGF1R DB01277 Mecasermin approved, investigational yes agonist
72 IGF1R DB04395 Phosphoaminophosphonic Acid-Adenylate Ester experimental unknown
73 IGF1R DB00030 Insulin human approved, investigational unknown
74 IGF1R DB00071 Insulin pork approved unknown
75 IGF1R DB05023 ATL1101 investigational unknown
76 IGF1R DB05184 XL228 investigational unknown
77 IGF1R DB12250 Cixutumumab investigational unknown
78 IGF1R DB05897 rhIGFBP-3 investigational unknown
79 IGF1R DB06075 Linsitinib investigational unknown
80 IGF1R DB06343 Teprotumumab approved, investigational unknown inhibitor
81 IGF1R DB07156 (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione experimental unknown
82 IGF1R DB07474 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE experimental unknown
83 IGF1R DB12267 Brigatinib approved, investigational unknown inhibitor
84 IGF1R DB09098 Somatrem approved, investigational, withdrawn yes
85 IGF1R DB00046 Insulin lispro approved unknown
86 IGF1R DB01307 Insulin detemir approved unknown
87 IGF1R DB00047 Insulin glargine approved unknown
88 IGF1R DB01306 Insulin aspart approved unknown
89 IGF1R DB01309 Insulin glulisine approved unknown
90 IGF1R DB09564 Insulin degludec approved unknown
91 IGF1R DB14751 Mecasermin rinfabate approved yes agonist
92 PIK3R1 DB01064 Isoprenaline approved, investigational unknown agonist
93 PIK3R1 DB05210 SF1126 investigational unknown
94 PIK3R1 DB06486 Enzastaurin investigational unknown
95 PIK3R1 DB08059 Wortmannin experimental unknown
96 EGFR DB15035 Zanubrutinib approved, investigational unknown inhibitor
97 EGFR DB12202 Zalutumumab investigational yes antagonist
98 EGFR DB05944 Varlitinib investigational unknown
99 EGFR DB05294 Vandetanib approved unknown inhibitor
100 EGFR DB07602 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE experimental unknown
101 EGFR DB05374 Rindopepimut investigational unknown
102 EGFR DB05524 Pelitinib investigational unknown
103 EGFR DB07662 PD-168393 experimental unknown
104 EGFR DB01269 Panitumumab approved, investigational yes suppressor
105 EGFR DB09330 Osimertinib approved yes inhibitor
106 EGFR DB13164 Olmutinib investigational yes inhibitor
107 EGFR DB11828 Neratinib approved, investigational yes inhibitor
108 EGFR DB09559 Necitumumab approved, investigational yes antagonist
109 EGFR DB05101 Matuzumab investigational unknown
110 EGFR DB00281 Lidocaine approved, vet_approved unknown antagonist
111 EGFR DB01259 Lapatinib approved, investigational yes antagonist
112 EGFR DB04988 IGN311 investigational unknown
113 EGFR DB11737 Icotinib experimental, investigational unknown antagonist
114 EGFR DB00317 Gefitinib approved, investigational yes antagonist
115 EGFR DB12010 Fostamatinib approved, investigational unknown inhibitor
116 EGFR DB10772 Foreskin keratinocyte (neonatal) approved yes agonist
117 EGFR DB00530 Erlotinib approved, investigational yes antagonist
118 EGFR DB11731 Depatuxizumab mafodotin investigational no antibody
119 EGFR DB11963 Dacomitinib approved, investigational yes inhibitor
120 EGFR DB00002 Cetuximab approved yes antagonist
121 EGFR DB05424 Canertinib investigational unknown
122 EGFR DB12267 Brigatinib approved, investigational yes inhibitor
123 EGFR DB06021 AV-412 investigational unknown
124 EGFR DB03496 Alvocidib experimental, investigational unknown
125 EGFR DB08916 Afatinib approved yes inhibitor
126 EGFR DB15327 Abivertinib investigational yes inhibitor
127 KRAS DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID experimental unknown
128 KRAS DB07780 Farnesyl diphosphate experimental unknown
129 KRAS DB15569 AMG-510 investigational yes inhibitor
130 KRAS DB15568 MRTX849 investigational yes inhibitor
131 ESR1 DB00255 Diethylstilbestrol approved, investigational yes agonist
132 ESR1 DB00269 Chlorotrianisene investigational, withdrawn yes agonist
133 ESR1 DB00286 Conjugated estrogens approved yes agonist
134 ESR1 DB00481 Raloxifene approved, investigational yes agonist
135 ESR1 DB00539 Toremifene approved, investigational yes modulator
136 ESR1 DB00655 Estrone approved yes agonist
137 ESR1 DB00783 Estradiol approved, investigational, vet_approved yes agonist
138 ESR1 DB00823 Ethynodiol diacetate approved yes agonist
139 ESR1 DB00882 Clomifene approved, investigational yes antagonistagonist
140 ESR1 DB00890 Dienestrol approved, investigational yes agonist
141 ESR1 DB00947 Fulvestrant approved, investigational yes antagonist
142 ESR1 DB00977 Ethinylestradiol approved yes agonist
143 ESR1 DB00304 Desogestrel approved yes agonist
144 ESR1 DB00367 Levonorgestrel approved, investigational yes other/unknown
145 ESR1 DB00396 Progesterone approved, vet_approved unknown agonistinhibitordownregulator
146 ESR1 DB00603 Medroxyprogesterone acetate approved, investigational yes agonist
147 ESR1 DB00957 Norgestimate approved, investigational yes agonist
148 ESR1 DB01185 Fluoxymesterone approved, illicit yes antagonist
149 ESR1 DB01196 Estramustine approved, investigational yes agonist
150 ESR1 DB01406 Danazol approved yes agonist
151 ESR1 DB01183 Naloxone approved, vet_approved no antagonistother/unknown
152 ESR1 DB02615 Compound 19 experimental unknown
153 ESR1 DB02715 Compound 18 experimental unknown
154 ESR1 DB03742 Compound 4-D experimental unknown
155 ESR1 DB03802 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol experimental unknown
156 ESR1 DB04468 Afimoxifene investigational unknown
157 ESR1 DB04471 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol experimental unknown
158 ESR1 DB04575 Quinestrol approved yes agonistmodulator
159 ESR1 DB00675 Tamoxifen approved yes antagonistagonist
160 ESR1 DB05233 AP1081 investigational unknown
161 ESR1 DB04938 Ospemifene approved, investigational yes antagonistagonist
162 ESR1 DB01357 Mestranol approved yes agonist
163 ESR1 DB04573 Estriol approved, investigational, vet_approved yes agonist
164 ESR1 DB05662 NP-50301 investigational unknown
165 ESR1 DB05487 Custirsen investigational unknown
166 ESR1 DB05882 CHF 4227 investigational unknown
167 ESR1 DB05966 TAS-108 investigational unknown
168 ESR1 DB06202 Lasofoxifene approved, investigational yes antagonistagonistnegative modulator
169 ESR1 DB06249 Arzoxifene approved, investigational unknown
170 ESR1 DB06374 Elacestrant investigational unknown
171 ESR1 DB01065 Melatonin approved, nutraceutical, vet_approved unknown antagonist
172 ESR1 DB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENIN experimental unknown
173 ESR1 DB06898 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol experimental unknown
174 ESR1 DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE experimental unknown
175 ESR1 DB07086 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL experimental unknown
176 ESR1 DB07087 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL experimental unknown
177 ESR1 DB07195 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL experimental unknown
178 ESR1 DB07567 (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL experimental unknown
179 ESR1 DB07638 (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL experimental unknown
180 ESR1 DB07678 (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL experimental unknown
181 ESR1 DB07707 (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL experimental unknown
182 ESR1 DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL experimental unknown
183 ESR1 DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL experimental unknown
184 ESR1 DB01645 Genistein investigational unknown
185 ESR1 DB07932 dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate experimental unknown
186 ESR1 DB07933 Erteberel experimental, investigational unknown
187 ESR1 DB07991 N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE experimental unknown
188 ESR1 DB08020 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL experimental unknown
189 ESR1 DB08047 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol experimental unknown
190 ESR1 DB08048 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL experimental unknown
191 ESR1 DB08320 DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE experimental unknown
192 ESR1 DB08398 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine investigational unknown
193 ESR1 DB08595 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL experimental unknown
194 ESR1 DB08737 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL experimental unknown
195 ESR1 DB08773 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol experimental unknown
196 ESR1 DB01108 Trilostane approved, investigational, vet_approved, withdrawn yes allosteric modulator
197 ESR1 DB01431 Allylestrenol experimental unknown agonist
198 ESR1 DB04574 Estrone sulfate approved yes agonist
199 ESR1 DB01708 Prasterone approved, investigational, nutraceutical unknown binder
200 ESR1 DB06401 Bazedoxifene approved, investigational yes antagonistagonist
201 ESR1 DB09317 Synthetic Conjugated Estrogens, A approved yes ligand
202 ESR1 DB09318 Synthetic Conjugated Estrogens, B approved yes ligand
203 ESR1 DB09070 Tibolone approved, investigational yes antagonistagonist
204 ESR1 DB03467 Naringenin experimental unknown
205 ESR1 DB06732 beta-Naphthoflavone experimental unknown
206 ESR1 DB04216 Quercetin experimental, investigational unknown
207 ESR1 DB09086 Eugenol approved unknown
208 ESR1 DB02901 Stanolone illicit, investigational unknown
209 ESR1 DB00624 Testosterone approved, investigational unknown inhibitor
210 ESR1 DB00648 Mitotane approved unknown
211 ESR1 DB02746 Phthalic Acid experimental unknown
212 ESR1 DB00431 Lindane approved, withdrawn unknown
213 ESR1 DB01593 Zinc approved, investigational unknown cofactor
214 ESR1 DB00756 Hexachlorophene approved, withdrawn unknown
215 ESR1 DB01878 Benzophenone experimental unknown
216 ESR1 DB09535 Octocrylene approved, investigational unknown
217 ESR1 DB01428 Oxybenzone approved, investigational unknown
218 ESR1 DB11219 Enzacamene approved unknown
219 ESR1 DB04930 Permethrin approved, investigational unknown
220 ESR1 DB02757 Pyrazole experimental unknown
221 ESR1 DB07931 Hexestrol withdrawn unknown
222 ESR1 DB12450 Propyl Gallate investigational unknown
223 ESR1 DB02709 Resveratrol investigational unknown
224 ESR1 DB11478 Zeranol experimental, vet_approved unknown
225 ESR1 DB09371 Norethynodrel approved unknown
226 ESR1 DB02187 Equilin experimental unknown
227 ESR1 DB11064 Homosalate approved, investigational unknown
228 ESR1 DB00841 Dobutamine approved unknown
229 ESR1 DB11541 Ractopamine vet_approved unknown
230 ESR1 DB06710 Methyltestosterone approved unknown
231 ESR1
232 ESR1 DB04824 Phenolphthalein approved, withdrawn unknown agonist
233 ESR1 DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol experimental unknown
234 ESR1 DB13943 Testosterone cypionate approved unknown
235 ESR1 DB13944 Testosterone enanthate approved unknown
236 ESR1 DB13946 Testosterone undecanoate approved, investigational unknown
237 ESR1 DB13951 Stanolone acetate experimental unknown
238 ESR1 DB13952 Estradiol acetate approved, investigational, vet_approved yes agonist
239 ESR1 DB13953 Estradiol benzoate approved, investigational, vet_approved yes agonist
240 ESR1 DB13954 Estradiol cypionate approved, investigational, vet_approved yes agonist
241 ESR1 DB13955 Estradiol dienanthate approved, investigational, vet_approved yes agonist
242 ESR1 DB13956 Estradiol valerate approved, investigational, vet_approved yes agonist
243 ESR1 DB09369 Polyestradiol phosphate approved yes agonist
244 ESR1 DB11619 Gestrinone approved unknown antagonistagonist
245 ESR1 DB14487 Zinc acetate approved, investigational unknown
246 ESR1 DB14533 Zinc chloride approved, investigational unknown binder
247 ESR1 DB14641 Estriol tripropionate experimental yes
248 ESR1 DB14548 Zinc sulfate, unspecified form approved, experimental unknown binder
249 ESR1 DB15690 Fluoroestradiol F-18 approved unknown binder
250 CDK6 DB03496 Alvocidib experimental, investigational unknown
251 CDK6 DB07379 (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol experimental unknown
252 CDK6 DB07795 Fisetin experimental unknown
253 CDK6 DB09073 Palbociclib approved, investigational yes inhibitor
254 CDK6 DB11730 Ribociclib approved, investigational yes antagonistinhibitor
255 CDK6 DB12001 Abemaciclib approved, investigational yes inhibitor
256 AKT2/PKBb DB07812 N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide experimental unknown
257 AKT2/PKBb DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE experimental unknown
258 AKT2/PKBb DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE experimental unknown
259 AKT2/PKBb DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE experimental unknown
260 CREBBP DB08655 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE experimental unknown
261 DNMT3A DB00721 Procaine approved, investigational, vet_approved unknown inhibitor
262 DB01262 Decitabine approved, investigational unknown inhibitor
263 PDGFRA DB01268 Sunitinib approved, investigational yes inhibitor
264 PDGFRA DB00619 Imatinib approved unknown antagonist
265 PDGFRA DB00102 Becaplermin approved, investigational unknown
266 PDGFRA DB12742 Amuvatinib investigational unknown
267 PDGFRA DB05146 XL820 investigational unknown
268 PDGFRA DB06043 Olaratumab approved, investigational yes antagonist
269 PDGFRA DB06589 Pazopanib approved yes inhibitor
270 PDGFRA DB06595 Midostaurin approved, investigational yes antagonistinhibitor
271 PDGFRA DB08896 Regorafenib approved yes inhibitor
272 PDGFRA DB08901 Ponatinib approved, investigational unknown inhibitor
273 PDGFRA DB09078 Lenvatinib approved, investigational yes inhibitor
274 PDGFRA DB09079 Nintedanib approved yes inhibitor
275 PDGFRA DB10772 Foreskin keratinocyte (neonatal) approved yes agonist
276 PDGFRA DB12010 Fostamatinib approved, investigational unknown inhibitor
277 PDGFRA DB12147 Erdafitinib approved, investigational unknown substrate
278 PDGFRA DB14840 Ripretinib approved yes inhibitor
279 PDGFRA DB14840 Ripretinib approved unknown inhibitor
280 FGFR2 DB00039 Palifermin approved yes agonistbinder
281 FGFR2 DB02491 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine experimental unknown
282 FGFR2 DB02058 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone experimental unknown
283 FGFR2 DB01041 Thalidomide approved, investigational, withdrawn yes antagonist
284 FGFR2 DB08896 Regorafenib approved yes inhibitor
285 FGFR2 DB08901 Ponatinib approved, investigational unknown inhibitor
286 FGFR2 DB09078 Lenvatinib approved, investigational yes inhibitor
287 FGFR2 DB09079 Nintedanib approved yes inhibitor
288 FGFR2 DB01901 Sucrosofate experimental unknown ligand
289 FGFR2 DB01109 Heparin approved, investigational unknown
290 RHOA DB04315 Guanosine-5'-Diphosphate experimental unknown
291 ATM DB00201 Caffeine approved unknown inhibitor
292 ATRX DB05210 SF1126 investigational unknown
293 ATRX DB00201 Caffeine approved unknown inhibitor
294 AXIN1 DB04447 1,4-Dithiothreitol experimental unknown
295 CASP8 DB12651 Bardoxolone investigational unknown
296 CASP8 DB11752 Bryostatin 1 investigational unknown inhibitor
297 PMS2 DB02930 Adenosine 5'-[gamma-thio]triphosphate experimental unknown
298 BRAF DB00398 Sorafenib approved, investigational yes inhibitor
299 BRAF DB05190 XL281 investigational unknown
300 BRAF DB05984 RAF-265 investigational unknown
301 BRAF DB06999 PLX-4720 experimental unknown
302 BRAF DB07000 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide experimental unknown
303 BRAF DB08553 (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime experimental unknown
304 BRAF DB08881 Vemurafenib approved yes inhibitor
305 BRAF DB08896 Regorafenib approved yes inhibitor
306 BRAF DB08912 Dabrafenib approved, investigational yes antagonistinhibitor
307 BRAF DB12010 Fostamatinib approved, investigational unknown inhibitor
308 HRAS DB02210 Hexane-1,6-Diol experimental unknown
309 HRAS DB03226 Trifluoroethanol experimental unknown
310 HRAS DB04137 Guanosine-5'-Triphosphate experimental unknown
311 HRAS DB04315 Guanosine-5'-Diphosphate experimental unknown
312 HRAS DB08751 N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE experimental unknown
313 DNMT3A DB00721 Procaine approved, investigational, vet_approved unknown inhibitor
314 DNMT3A DB01262 Decitabine approved, investigational unknown inhibitor
315 SMAD2 DB04522 Dexfosfoserine experimental unknown
316 NR1I2 DB00783 Estradiol approved, investigational, vet_approved unknown binder
317 NR1I2 DB00977 Ethinylestradiol approved unknown agonist
318 NR1I2 DB01892 Hyperforin nutraceutical unknown
319 NR1I2 DB04466 SR12813 experimental unknown
320 NR1I2 DB00163 Vitamin E approved, nutraceutical, vet_approved unknown
321 NR1I2 DB01045 Rifampicin approved unknown agonist
322 NR1I2 DB01220 Rifaximin approved, investigational no agonist
323 NR1I2 DB07080 TO-901317 experimental unknown
324 NR1I2 DB00530 Erlotinib approved, investigational yes agonist
325 NR1I2 DB08864 Rilpivirine approved unknown agonist
326 STAT5B DB01254 Dasatinib approved, investigational unknown inhibitor
327 RAD51 DB12742 Amuvatinib investigational unknown
328 RAD51 DB04395 Phosphoaminophosphonic Acid-Adenylate Ester experimental unknown
329 POU2F1 DB01203 Nadolol approved unknown substrate
330 SRSF1 DB09130 Copper approved, investigational unknown
331 NR1H3 DB07080 TO-901317 experimental unknown
332 NR1H3 DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE experimental unknown
333 NR1H3 DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE experimental unknown
334 NR1H3 DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID experimental unknown
335 NR1H3 DB13174 Rhein experimental unknown inhibitor
336 NR1H3 DB11994 Diacerein approved, investigational unknown inhibitor
337 FOS DB08813 Nadroparin approved, investigational unknown inhibitor
338 NR1I3 DB01889 16,17-Androstene-3-Ol experimental unknown
339 NR1I3 DB07557 3,20-Pregnanedione experimental unknown
340 NR1I3 DB01708 Prasterone approved, investigational, nutraceutical unknown activator
341 NR1I3 DB00737 Meclizine approved unknown inverse agonist
342 NR1I3 DB04540 Cholesterol approved, investigational unknown
343 NR1I3 DB00366 Doxylamine approved, vet_approved unknown
344 NR1I3 DB07931 Hexestrol withdrawn unknown
345 NR1I3 DB01026 Ketoconazole approved, investigational unknown
346 NR1I3 DB00836 Loperamide approved unknown
347 NR1I3 DB01620 Pheniramine approved unknown
348
349
350
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352
353
354
355
356
357
358
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